Effects of weight management interventions on maternal and fetal outcomes in pregnancy:
 Individual patient data (IPD) meta analysis of randomised trials and model based economic evaluation


iWIP Collaborators
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iWIP Team



Maternal obesity and excess weight gain in pregnancy are associated with maternal and fetal complications in pregnancy and in the long term. Our recent HTA project on diet and lifestyle interventions showed that weight management interventions in pregnancy are effective in reducing maternal weight gain compared to standard care, with diet based interventions most effective. The findings were based published studies. However, the effects of weight management interventions in women with varied pre pregnancy weight (normal, overweight or obese), ethnicity, teenage pregnancies and socioeconomic status was difficult to ascertain. Furthermore, the relationship between the amount of weight change in pregnancy and risk of maternal and fetal complications was not known.

The technique of combining the data from individual patients in the studies to generate estimates of benefit is known as Individual Patient Data (IPD) Meta-analysis. To address the above gaps in evidence, we have established a collaborative (i-WIP International Weight Management in Pregnancy) Network of researchers who have conducted studies on weight management interventions in pregnancy. The Network has access to over 4000 individual patient data.

By pooling the individual data together, we will be able to estimate with increased confidence, the differential effects if any of the weight management interventions in various groups, allowing us to target the population that needs the most support for a beneficial outcome. It will also generate recommendations on optimal weight gain in pregnancy to minimise maternal and fetal complications and the cost effectiveness of these interventions.


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